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In a very latest analyze, we documented the identification and the characterization of a new atypical opioid receptor with unique detrimental regulatory Attributes toward opioid peptides.1 Our effects confirmed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a wide-spectrum scavenger